ceesdekker.net Fundamentals Explained
ceesdekker.net Fundamentals Explained
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Nanotechnology provides A variety of chances to add to biology. In this article I'll existing illustrations where nanofabrication – the ability to make confined structures with dimensions at will – is utilised to look at the biophysics of solitary molecules and cells. I'll current some illustrations from our lab:
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, Groningen scientists existing the effects in their efforts to make labs much more sustainable and provide techniques for other labs.
Nanofabrication of electrodes with sub-5 nm spacing for transportation experiments on solitary molecules and steel clusters
2015, discovery that condensin is often a extremely adaptable protein framework; and very first detection of DNA knots utilizing nanopores
Illustration (3) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is demonstrated in grey, the rim of your pore is highlighted in purple, along with a 3D rendering of the movement in the DNA rod is displayed.
Due to the fact 2000 he moved to solitary-molecule biophysics and nanobiology, with study from DNA supercoiling research of nucleosomes and DNA repair proteins to DNA translocation as a result of nanopores. Not long ago his investigation has focused on researching cell division with germs on chip, while his best curiosity is within the way of acknowledging synthetic cells.
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‘You shouldn't just contemplate the issues of tomorrow, but will also evaluate the issues of your working day immediately after tomorrow’
‘The fantastically subtle way wherein things in character perform by no means ceases to amaze me. If we solve the puzzle of how everyday living arrived into getting, I anticipate that my amazement at the complexity of generation could have improved and with it my awe for the greatness of your Creator.’
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2001, discovery of single-electron transistors at space temperature depending on nanotubes; realization of 1st logic circuits with https://www.ceesdekker.net carbon nanotube units; and discovery with the molecular composition of DNA repair enzymes with AFM
Visualization of unstained DNA nanostructures with Innovative in-aim transmission electron microscopy techniques
Supercoiling-dependent DNA binding: quantitative modeling and programs to bulk and single-molecule experiments